Enhanced Induction of Immune Resistance by Concanavalin A- bound L1210 Vaccine and an Immunopotentiator Prepared from Coholus versicolor^
نویسندگان
چکیده
treated with glutaraldehyde and concanavalin A and a protein-bound polysaccharide preparation of Coriolus ver sicolor induced synergistic resistance to L1210 leukemia in BALB/c x DBA/2Cr F, mice. This effect was dependent on the dose and timing of the administration of the proteinbound polysaccharide preparation, being most effective at the time of or 1 day after the second vaccination. Induced resistance was not cross-reactive with P388 murine leuke mia, indicating specificity of resistance. This immunopotentiation by the protein-bound polysaccharide did not occur when L1210 cells treated with glutaraldehyde, but not with concanavalin A, were used as a vaccine.
منابع مشابه
Enhanced induction of immune resistance by concanavalin A-bound L1210 vaccine and an immunopotentiator prepared from Coriolus versicolor.
Combined administration of a vaccine consisting of a small number (2 X 10(6)) of L1210 murine leukemic cells treated with glutaraldehyde and concanavalin A and a protein-bound polysaccharide preparation of Coriolus versicolor induced synergistic resistance to L1210 leukemia in BALB/c X DBA/2CrF1 mice. This effect was dependent on the dose and timing of the administration of the protein-bound po...
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